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研究実績

業績（2007以降）

2023

  1. Phengma P, Khamrin P, Jampanil N, Yodmeeklin A, Ushijima H, Maneekarn N, Kumthip K.The emergence of recombinant norovirus GII.12[P16] and predominance of GII.3[P12] strains in pediatric patients with acute gastroenteritis in Thailand, 2019-2020.J Med Virol. 2023 Jan;95(1):e28321. 
  2. Takano C, Ogawa E, Hayakawa S.Insulin Resistance in Mitochondrial Diabetes.Biomolecules. 2023 Jan 7;13(1):126. 
  3. Takada K, Melnikov VG, Kobayashi R, Komine-Aizawa S, Tsuji NM, Hayakawa S.Female reproductive tract-organ axes.Front Immunol. 2023 Jan 31;14:1110001.
  4. Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H.Abundance of viral gastroenteritis before and after the emergence of COVID-19: Molecular evidence on wastewater.J Infect. 2023 Feb;86(2):154-225.
  5. Kumthip K, Khamrin P, Ushijima H, Maneekarn N.Detection of Six Different Human Enteric Viruses Contaminating Environmental Water in Chiang Mai, Thailand. Microbiol Spectr. 2023 Feb 14;11(1):e0351222.
  6. Matsuda E, Takada K, Kobayashi O, Nakajima T, Ikeda Y, Asai-Sato M, Kawakami K, Komatsu A, Chishima F, Komine-Aizawa S, Hayakawa S, Kawana K.Pathological roles of antimicrobial peptides and pro-inflammatory factors secreted from the cervical epithelium in Gardnerella vaginalis-abundant vaginal flora in pregnancy.J Reprod Immunol. 2023 Mar;156:103797.
  7. Sheikh Ariful Hoque  , Kazi Selim Anwar , Md. Azraf Hossain Khan , Ummay Nasrin Sultana , Md. Ahasan Ali , Tania Hossain , Laila Shamima Sharmin , ARM Luthful Kabir , Md. Abid Hossain Mollah , Sk. Azimul Hoque , Masuma Khan , Ngan Thi Kim Pham , Pattara Khamrin , Shoko Okitsu , Satoshi Hayakawa , Hiroshi Ushijima. Emergence of Coxsackievirus A16 Causing Childhood Hand, Foot, and Mouth Disease: First Molecular Evidence from Bangladesh. J Pediatr Infect Dis 2023; 18(04): 220-225
  8. Abe Y, Takano C, Tie J, Isobe E, Ohirabaru A, Isahai I, Nishiyama H, Jike T, Masuda S, Okuda T.Sudden death of a child associated with invasive non-typeable Haemophilus influenzae infection with underlying IgG2 subclass deficiency.Leg Med (Tokyo). 2023 May;62:102240.
  9. Hikita T, Phan T, Okitsu S, Hayakawa S, Ushijima H.A Comparative Study of Acute Gastroenteritis Symptoms in Single- versus Multiple-Virus Infections.Int J Mol Sci. 2023 May 6;24(9):8364.
  10. Chan-It W, Chanta C, Ushijima H.Predominance of DS-1-like G8P[8] rotavirus reassortant strains in children hospitalized with acute gastroenteritis in Thailand, 2018-2020.J Med Virol. 2023 Jun;95(6):e28870.
  11. Kawana K, Fukui A, Chishima F, Takada K, Itoh M. Editorial (JSIR2021 Special issue). J Reprod Immunol. 2023 Jun 9;158:103976.
  12. Okitsu S, Khamrin P, Hikita T, Shimizu-Onda Y, Thongprachum A, Hayakawa S, Maneekarn N, Ushijima H.Molecular Epidemiology of Classic, MLB, and VA Astroviruses in Children with Acute Gastroenteritis, 2014-2021: Emergence of MLB3 Strain in Japan.Microbiol Spectr. 2023 Jun 15;11(3):e0070023.
  13. Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H.Genotype Diversity of Enteric Viruses in Wastewater Amid the COVID-19 Pandemic.Food Environ Virol. 2023 Jun;15(2):176-191. 
  14. Wei H, Kumthip K, Khamrin P, Yodmeeklin A, Jampanil N, Phengma P, Xie Z, Ukarapol N, Ushijima H, Maneekarn N.Triple Intergenotype Recombination of Human Astrovirus 5, Human Astrovirus 8, and Human Astrovirus 1 in the Open Reading Frame 1a, Open Reading Frame 1b, and Open Reading Frame 2 Regions of the Human Astrovirus Genome.Microbiol Spectr. 2023 Jun 15;11(3):e0488822. 
  15. Sharif N, Ahmed SN, Sharif N, Alzahrani KJ, Alsuwat MA, Alzahrani FM, Khandaker S, Monifa NH, Okitsu S, Parvez AK, Ushijima H, Dey SK.High prevalence of norovirus GII.4 Sydney among children with acute gastroenteritis in Bangladesh, 2018-2021.J Infect Public Health. 2023 Jul;16(7):1015-1022. 
  16. Khamrin P, Pham NTK, Shimizu-Onda Y, Trinh QD, Hoque SA, Kumthip K, Nomura A, Okitsu S, Maneekarn N, Müller WEG, Hayakawa S, Ushijima H.Evaluation of an Immunochromatographic Test for Rapid Detection of Astrovirus in Acute Gastroenteritis Pediatric Patients.Clin Lab. 2023 Aug 1;69(8). 
  17. Ushijima H, Nishimura S, Shimizu-Onda Y, Thi Kim Pham N, Trinh QD, Okitsu S, Takano C, Kumthip K, Hoque SA, Komine-Aizawa S, Maneekarn N, Hayakawa S, Khamrin P.Outbreak of human astroviruses 1 and Melbourne 2 in acute gastroenteritis pediatric patients in Japan during the COVID-19 pandemic, 2021.J Infect Public Health. 2023 Aug;16(8):1301-1305. 

2022

  1. Namiki T, Takano C, Aoki R, Trinh QD, Morioka I, Hayakawa S.Parenchymal calcification is associated with the neurological prognosis in patients with congenital rubella syndrome.Congenit Anom (Kyoto). 2022 Jan;62(1):38-41. 
  2. Hoque SA, Wakana A, Shimizu H, Takanashi S, Okitsu S, Anwar KS, Hayakawa S, Maneekarn N, Okabe N, Ushijima H. Detection of Rotavirus Strains in Freshwater Clams in Japan. Food Environ Virol. 2022 Mar;14(1):94-100.
  3. Hoque SA, Nishimura K, Thongprachum A, Khamrin P, Thi Kim Pham N, Islam MT, Khandoker N, Okitsu S, Onda-Shimizu Y, Dey SK, Maneekarn N, Kobayashi T, Hayakawa S, Ushijima H. An increasing trend of human sapovirus infection in Japan, 2009 to 2019: An emerging public health concern. J Infect Public Health. 2022 Mar;15(3):315-320. 
  4. Trinh QD.Recent Research in Cell Stress and Microbial Infection. Microorganisms. 2022 Mar 14;10(3):622.
  5. Iijima T, Ando S, Kanamori D, Kuroda K, Nomura T, Tisi L, Kilgore PE, Percy N, Kohase H, Hayakawa S, Seki M, Hoshino T.Detection of SARS-CoV-2 and the L452R spike mutation using reverse transcription loop-mediated isothermal amplification plus bioluminescent assay in real-time (RT-LAMP-BART).PLoS One. 2022 Mar 21;17(3):e0265748.
  6. Shingo Hayashida, Kazuhide Takada, Vyacheslav G. Melnikov, Shihoko Komine-Aizawa, Noriko M. Tsuji, Satoshi Hayakawa. How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus. Medical Hypotheses, Volume 163, June 2022, 110858.
  7. Phan T, Kobayashi M, Nagasawa K, Hatazawa R, Thi Kim Pham N, Miyashita H, Komoto S, Tajima T, Baba T, Okitsu S, Khamrin P, Maneekarn N, Kimura H, Kobayashi T, Hayakawa S, Ushijima H.Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan. Virusdisease. 2022 Jun;33(2):215-218.
  8. Khamrin P, Kumthip K, Yodmeeklin A, Jampanil N, Phengma P, Yamsakul P, Okitsu S, Kobayashi T, Ushijima H, Maneekarn N.Changing Predominance of Norovirus Recombinant Strains GII.2[P16] to GII.4[P16] and GII.4[P31] in Thailand, 2017 to 2018. Microbiol Spectr. 2022 Jun 29;10(3):e0044822. 
  9. Komine-Aizawa S, Haruyama Y, Deguchi M, Hayakawa S, Kawana K, Kobashi G, Miyagi E, Yamada H, Sugiyama T.The vaccination status and adverse effects of COVID-19 vaccine among pregnant women in Japan in 2021.J Obstet Gynaecol Res. 2022 Jul;48(7):1561-1569.
  10. Phan T, Hatazawa R, Komoto S, Nishimura S, Khamrin P, Pham NTK, Okitsu S, Kobayashi T, Maneekarn N, Hayakawa S, Ushijima H.Whole genome sequence of an uncommon G9P[4] species A rotavirus containing DS-1-like (genotype 2) genes in Japan.Arch Virol. 2022 Jul;167(7):1603-1606. 
  11. Namiki T, Komine-Aizawa S, Takada K, Takano C, Trinh QD, Hayakawa S.Adverse events after BNT162b2 mRNA COVID-19 vaccination in health care workers and medical students in Japan.J Infect Chemother. 2022 Aug;28(8):1220-1224.
  12. Kimura M, Sekiguchi K, Okitsu S, Ushijima H, Tani H.A highly quantitative detection system for cell entry of human norovirus-like particles based on the complementation of NanoLuc luciferase. Virology. 2022 Aug;573:23-28.
  13. Pham NTK, Nishimura S, Shimizu-Onda Y, Trinh QD, Komine-Aizawa S, Khamrin P, Okitsu S, Sato S, Kobayashi T, Maneekarn N, Hayakawa S, Ushijima H.Emerging norovirus GII.4 Sydney[P31] causing acute gastroenteritis outbreak in children in Japan, during COVID-19, 2021.J Infect Chemother. 2022 Sep;28(9):1347-1351. 
  14. Fujimoto D, Fukuya M, Terao S, Irei I, Akiyama T, Watanabe A, Yasuda Y, Yoshioka D, Takada K, Hayakawa S, Moriya T.Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike protein.Med Mol Morphol. 2022 Dec;55(4):316-322.
  15. Pham NTK, Trinh QD, Takada K, Komine-Aizawa S, Hayakawa S.Low Susceptibility of Rubella Virus in First-Trimester Trophoblast Cell Lines.Viruses. 2022 May 27;14(6):1169. 
  16. Okitsu S, Khamrin P, Hikita T, Thongprachum A, Pham NTK, Hoque SA, Hayakawa S, Maneekarn N, Ushijima H.Changing distribution of rotavirus A genotypes circulating in Japanese children with acute gastroenteritis in outpatient clinic, 2014-2020.J Infect Public Health. 2022 Jul;15(7):816-825. 
  17. Trinh QD, Takada K, Pham NTK, Takano C, Namiki T, Ikuta R, Hayashida S, Okitsu S, Ushijima H, Komine-Aizawa S, Hayakawa S.Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions.Front Microbiol. 2022 Jul 8;13:904189. 
  18. Takano C, Horie M, Taiko I, Trinh QD, Kanemaru K, Komine-Aizawa S, Hayakawa S, Miki T.Inhibition of Epithelial-Mesenchymal Transition Maintains Stemness in Human Amniotic Epithelial Cells.Stem Cell Rev Rep. 2022 Dec;18(8):3083-3091.
  19. Suzaki A, Komine-Aizawa S, Nishiyama H, Hayakawa S.Massive intravascular hemolysis is an important factor in Clostridium perfringens-induced bacteremia.Intern Emerg Med. 2022 Oct;17(7):1959-1967.
  20. Takada K, Shimodai-Yamada S, Suzuki M, Trinh QD, Takano C, Kawakami K, Asai-Sato M, Komatsu A, Okahashi A, Nagano N, Misawa T, Yamaguchi K, Suzuki T, Kawana K, Morioka I, Yamada H, Hayakawa S, Hao H, Komine-Aizawa S.Restriction of SARS-CoV-2 replication in the human placenta.Placenta. 2022 Sep;127:73-76. 
  21. Trinh QD, Pham NTK, Takada K, Takano C, Komine-Aizawa S, Hayakawa S.TGF-β1 Promotes Zika Virus Infection in Immortalized Human First-Trimester Trophoblasts via the Smad Pathway.Cells. 2022 Sep 27;11(19):3026. 
  22. Tatsuoka J, Sano E, Hanashima Y, Yagi C, Yamamuro S, Sumi K, Hara H, Takada K, Kanemaru K, Komine-Aizawa S, Katayama Y, Yoshino A.Anti-tumor effects of perampanel in malignant glioma cells.Oncol Lett. 2022 Oct 7;24(6):421. 
  23. Namiki T, Komine-Aizawa S, Takada K, Takano C, Trinh QD, Hayakawa S.The association of three doses of the BNT162b2 mRNA vaccine with abnormal bleeding and an irregular menstrual cycle among premenopausal females: A single institute observation study.J Obstet Gynaecol Res. 2022 Nov;48(11):2903-2910. 

2021

  1. Phan T, Ide T, Komoto S, Khamrin P, Pham NTK, Okitsu S, Taniguchi K, Nishimura S, Maneekarn N, Hayakawa S, Ushijima H.Genomic analysis of group A rotavirus G12P[8] including a new Japanese strain revealed evidence for intergenotypic recombination in VP7 and VP4 genes.Infect Genet Evol. 2021 Jan;87:104656.
  2. Kanai Y, Onishi M, Kawagishi T, Pannacha P, Nurdin JA, Nouda R, Yamasaki M, Lusiany T, Khamrin P, Okitsu S, Hayakawa S, Ebina H, Ushijima H, Kobayashi T. Reverse Genetics Approach for Developing Rotavirus Vaccine Candidates Carrying VP4 and VP7 Genes Cloned from Clinical Isolates of Human Rotavirus.J Virol. 2021 January;95(2):e01374-20. 
  3. Pham NTK, Thongprachum A, Shimizu Y, Shiota I, Hoque SA, Khamrin P, Takano C, Trinh QD, Okitsu S, Komine-Aizawa S, Shimizu H, Maneekarn N, Hayakawa S, Ushijima H.Genetic diversity of Parechovirus A in infants and children with acute gastroenteritis in Japan during 2016-2018.Infect Genet Evol. 2021 Jun;90:104776.
  4. Takano C, Ishige M, Ogawa E, Nagano N, Morohashi T, Okahashi A, Kawakami K, Komatsu A, Kawana K, Urakami T, Morioka I.Nutrient management in the intrapartum period in maternal maple syrup urine disease.Mol Genet Metab Rep. 2021 Jan 29;26:100711.
  5. Lee J, Yoon Y, Kim EJ, Lee D, Baek Y, Takano C, Chang B, Iijima T, Kilgore PE, Hayakawa S, Hoshino T, Kim DW, Seki M.23-valent polysaccharide vaccine (PPSV23)-targeted serotype-specific identification of Streptococcus pneumoniae using the loop-mediated isothermal amplification (LAMP) method.PLoS One. 2021 Feb 16;16(2):e0246699. 
  6. Sasou A, Yuki Y, Kurokawa S, Sato S, Goda Y, Uchida M, Matsumoto N, Sagara H, Watanabe Y, Kuroda M, Sakon N, Sugiura K, Nakahashi-Ouchida R, Ushijima H, Fujihashi K, Kiyono H.Development of Antibody-Fragment-Producing Rice for Neutralization of Human Norovirus.Front Plant Sci. 2021 Feb 23;12:639953.
  7. Kyo K, Takano C, Kasuga Y, Ogawa E, Ishige M, Pham NTK, Okitsu S, Ushijima H, Urakami T, Fuchigami T, Hayakawa S, Morioka I.Severe rotavirus gastroenteritis in children older than 5 years after vaccine introduction.J Infect Chemother. 2021 Apr;27(4):598-603.
  8. Nangaku M, Kadowaki T, Yotsuyanagi H, Ohmagari N, Egi M, Sasaki J, Sakamoto T, Hasegawa Y, Ogura T, Chiba S, Node K, Suzuki R, Yamaguchi Y, Murashima A, Ikeda N, Morishita E, Yuzawa K, Moriuchi H, Hayakawa S, Nishi D, Irisawa A, Miyamoto T, Suzuki H, Sone H, Fujino Y.The Japanese Medical Science Federation COVID-19 Expert Opinion English Version.JMA J. 2021 Apr 15;4(2):148-162.
  9. Sharif N, Ahmed SN, Opu RR, Daullah MU, Khan S, Talukder AA, Okitsu S, Ushijima H, Zhang M, Dey SK.Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.Epidemiol Infect. 2021 Apr 28;149:e103.
  10. Sato Y, Aoki R, Nagano N, Takano C, Seimiya A, Kato R, Ogawa E, Ishige M, Okazaki Y, Murayama K, Morioka I.Unique and abnormal subependymal pseudocysts in a newborn with mitochondrial disease.Sci Prog. 2021 Apr-Jun;104(2):368504211011873. 
  11. Takano C, Grubbs BH, Ishige M, Ogawa E, Morioka I, Hayakawa S, Miki T.Clinical perspective on the use of human amniotic epithelial cells to treat congenital metabolic diseases with a focus on maple syrup urine disease.Stem Cells Transl Med. 2021 Feb 6. doi: 10.1002/sctm.20-0225.
  12. Okitsu S, Khamrin P, Thongprachum A, Hikita T, Kumthip K, Pham NTK, Takanashi S, Hayakawa S, Maneekarn N, Ushijima H.Diversity of human sapovirus genotypes detected in Japanese pediatric patients with acute gastroenteritis, 2014-2017.J Med Virol. 2021 Mar 11. doi: 10.1002/jmv.26934.
  13. Hayakawa S, Komine-Aizawa S, Takada K, Kimura T, Yamada H.Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan.J Obstet Gynaecol Res. 2021 Mar 23. doi: 10.1111/jog.14748.
  14. Pham NTK, Trinh QD, Takada K, Takano C, Sasano M, Okitsu S, Ushijima H, Komine-Aizawa S, Hayakawa S.The Epithelial-to-Mesenchymal Transition-Like Process Induced by TGF-β1 Enhances Rubella Virus Binding and Infection in A549 Cells via the Smad Pathway.Microorganisms. 2021 Mar 23;9(3):662.
  15. Sasano M, Seki M, Takano C, Komine-Aizawa S, Hayakawa S.An improved primer design for the loop-mediated isothermal amplification (LAMP) method to detect oxacillinase (OXA)-48 β-lactamase genes in Gram-negative bacteria for clinical applications.J Infect Chemother. 2021 Apr 1:S1341-321X(21)00056-8. 
  16. Kawata K, Hoque SA, Nishimura S, Yagyu F, Islam MT, Sharmin LS, Pham NTK, Onda-Shimizu Y, Quang TD, Takanashi S, Okitsu S, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H.Role of rotavirus vaccination on G9P[8] rotavirus strain during a seasonal outbreak in Japan.Hum Vaccin Immunother. 2021 May 25:1-6.
  17. Kumthip K, Khamrin P, Ushijima H, Maneekarn N. Predominance of Human Bocavirus Genotypes 1 and 2 in Oysters in Thailand. Appl Environ Microbiol. 2021 Jul 27;87(16):e0045621.
  18. Suzaki A, Ohtani K, Komine-Aizawa S, Matsumoto A, Kamiya S, Hayakawa S.Pathogenic Characterization of Clostridium perfringens Strains Isolated From Patients With Massive Intravascular Hemolysis.Front Microbiol. 2021 Jul 27;12:713509.
  19. Tohma K, Lepore CJ, Martinez M, Degiuseppe JI, Khamrin P, Saito M, Mayta H, Nwaba AUA, Ford-Siltz LA, Green KY, Galeano ME, Zimic M, Stupka JA, Gilman RH, Maneekarn N, Ushijima H, Parra GI.Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination constraints.PLoS Pathog. 2021 Jul 13;17(7):e1009744.
  20. Yoshida T, Takada K, Komine-Aizawa S, Kamei Y, Ishihara O, Hayakawa S.Lactobacillus crispatus promotes invasion of the HTR-8/SVneo trophoblast cell line.Placenta. 2021 Aug;111:76-81.
  21. Abe Y, Kusano C, Takano C, Morioka I, Gotoda T.Association between Helicobacter pylori antibody-positive status and extragastric diseases in Japanese junior high school students.Pediatr Int. 2021 Sep;63(9):1087-1094. 
  22. Abramov VM, Kosarev IV, Priputnevich TV, Machulin AV, Abashina TN, Chikileva IO, Donetskova AD, Takada K, Melnikov VG, Vasilenko RN, Khlebnikov VS, Samoilenko VA, Nikonov IN, Sukhikh GT, Uversky VN, Karlyshev AV.S-layer protein 2 of vaginal Lactobacillus crispatus 2029 enhances growth, differentiation, VEGF production and barrier functions in intestinal epithelial cell line Caco-2.Int J Biol Macromol. 2021 Oct 31;189:410-419. 
  23. Endo-Umeda K, Nakashima H, Uno S, Toyoshima S, Umeda N, Komine-Aizawa S, Seki S, Makishima M.Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice.Sci Rep. 2021 Nov 19;11(1):22595.
  24. Komine-Aizawa S, Mizuno S, Matsuo K, Namiki T, Hayakawa S, Honda M.Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii.Vaccines (Basel). 2021 Nov 1;9(11):1260.
  25. Jampanil N, Kumthip K, Yodmeeklin A, Kanai Y, Okitsu S, Kobayashi T, Ukarapol N, Ushijima H, Maneekarn N, Khamrin P.Epidemiology and genetic diversity of group A rotavirus in pediatric patients with acute gastroenteritis in Thailand, 2018-2019.Infect Genet Evol. 2021 Nov;95:104898. 
  26. Horii T, Suzuki S, Takano C, Shibuya H, Ichijima R, Kusano C, Ikehara H, Gotoda T.Lower impact of vonoprazan-amoxicillin dual therapy on gut microbiota for Helicobacter pylori eradication.J Gastroenterol Hepatol. 2021 Dec;36(12):3314-3321.

2020

  1. Kanai Y, Tajima T, Ushijima H, Kobayashi T.Reverse Genetics System for a Human Group A Rotavirus. J Virol. 2020 Jan 6;94(2). pii: e00963-19.
  2. Okitsu S, Khamrin P, Takanashi S, Thongprachum A, Hoque SA, Takeuchi H, Khan MA, Hasan SMT, Iwata T, Shimizu H, Jimba M, Hayakawa S, Maneekarn N, Ushijima H. Molecular detection of enteric viruses in the stool samples of children without diarrhea in Bangladesh. Infect Genet Evol. 2020 Jan;77:104055.
  3. Imai K, Nemoto R, Kodana M, Tarumoto N, Sakai J, Kawamura T, Ikebuchi K, Mitsutake K, Murakami T, Maesaki S, Fujiwara T, Hayakawa S, Hoshino T, Seki M, Maeda T. Rapid and Accurate Species Identification of Mitis Group Streptococci Using the MinION Nanopore Sequencer.  Front Cell Infect Microbiol. 2020 Jan; 10:11.
  4. Namiki T, Hayakawa S. Possible Importance of Carcasses for Ebolavirus Persistence in the Ecosystem. Med Hypotheses. 2020 Jan 24;138:109595.
  5. Kumthip K, Khamrin P, Ushijima H, Chen L, Li S, Maneekarn N.Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010-2018.PeerJ. 2020 Feb 6;8:e8520.
  6. Sharif N, Parvez AK, Haque A, Talukder AA, Ushijima H, Dey SK. Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019.J Med Virol. 2020 Apr 1. doi: 10.1002/jmv.25812. 
  7. Hoque SA, Khandoker N, Thongprachum A, Khamrin P, Takanashi S, Okitsu S, Nishimura S, Kikuta H, Yamamoto A, Sugita K, Baba T, Kobayashi M, Hayakawa S, Mizuguchi M, Maneekarn N, Ushijima H.Distribution of rotavirus genotypes in Japan from 2015 to 2018: Diversity in genotypes before and after introduction of rotavirus vaccines.Vaccine. 2020 Apr 16. pii: S0264-410X(20)30465-5.
  8. Khamrin P, Kumthip K, Thongprachum A, Sirilert S, Malasao R, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N.Genetic diversity of norovirus genogroup I, II, IV and sapovirus in environmental water in Thailand.J Infect Public Health. 2020 May 31:S1876-0341(20)30470-6.
  9. Mori T, Kitani Y, Hatakeyama D, Machida K, Goto-Inoue N, Hayakawa S, Yamamoto N, Kashiwagi K, Kashiwagi A. Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles. Sci Rep. 2020. 10, 11737.
  10. Komine-Aizawa S, Aizawa S, Takano C, Hayakawa S.Interleukin-22 promotes the migration and invasion of oral squamous cell carcinoma cells.Immunol Med. 2020 Jun 16:1-9.
  11. Komine-Aizawa S, Ito S, Aizawa S, Namiki T, Hayakawa S.Cow milk exosomes activate NK cells and γδT cells in human PBMCs in vitro.Immunol Med. 2020 Jul 10:1-10.
  12. Komine-Aizawa S, Takada K, Hayakawa S.Placental barrier against COVID-19.Placenta. 2020 Jul 25;99:45-49.
  13. Hayakawa S, Komine-Aizawa S, Mor GG.Covid-19 pandemic and pregnancy.J Obstet Gynaecol Res. 2020 Aug 10:10.1111/jog.14384. doi: 10.1111/jog.14384. 
  14. Umazume T, Miyagi E, Haruyama Y, Kobashi G, Saito S, Hayakawa S, Kawana K, Ikenoue S, Morioka I, Yamada H.Survey on the use of personal protective equipment and COVID-19 testing of pregnant women in Japan.J Obstet Gynaecol Res. 2020 Aug 10:10.1111/jog.14382. doi: 10.1111/jog.14382.
  15. Rojjanadumrongkul K, Kumthip K, Khamrin P, Ukarapol N, Ushijima H, Maneekarn N.Enterovirus infections in pediatric patients hospitalized with acute gastroenteritis in Chiang Mai, Thailand, 2015-2018.PeerJ. 2020 Aug 17;8:e9645. 
  16. Phan T, Ide T, Komoto S, Khamrin P, Okitsu S, Taniguchi K, Kikuta H, Maneekarn N, Hayakawa S, Ushijima H.Unusual mono-reassortant of a Wa-like G1P[8] species A rotavirus containing a DS-1-like (genotype 2) NSP4 gene.Virus Genes. 2020 Oct;56(5):638-641.
  17. Takada K, Sasano M, Hayakawa S. A legendary sumo wrestler with gigantism or acromegaly? The case of Ikezuki Geitazaemon (1827–1850). Medical Hypotheses. 2020.144:110174.
  18. Tarumoto N, Imai K, Nakayama SI, Itoda I, Sakai J, Murakami T, Maesaki S, Hayakawa S, Ohnishi M, Maeda T.A novel peptide nucleic acid- and loop-mediated isothermal amplification assay for the detection of mutations in the 23S rRNA gene of Treponema pallidum.J Med Microbiol. 2020 Nov 12. 
  19. Kanai Y, Onishi M, Kawagishi T, Pannacha P, Nurdin J, Nouda R, Yamasaki M, Lusiany T, Khamrin P, Okitsu S, Hayakawa S, Ebina H, Ushijima H, Kobayashi T. Reverse genetics approach for developing rotavirus vaccine candidates carrying VP4 and VP7 genes cloned from clinical isolates of human rotavirus.J Virol. 2020 Oct 21:JVI.01374-20. 
  20. Namiki T, Komine‐Aizawa S, Takada K, Hayakawa S. Asian tiger mosquitos (Aedes albopictus) in urban Tokyo, Japan show low cytochrome c oxidase subunit 1 diversity. Entomological Science. 2020 November 12.  https://doi.org/10.1111/ens.12446
  21. Shaha M, Sifat SF, Mamun MA et al. Comparative evaluation of sensitivity and specificity of immunochromatography kit for the rapid detection of norovirus and rotavirus in Bangladesh [version 2; peer review: 3 approved with reservations]. F1000Research 2020, 8:173

2019

  1. Komine-Aizawa S, Aizawa S, Hayakawa S. Periodontal diseases and adverse pregnancy outcomes. J Obstet Gynaecol Res. 2019 Jan;45(1):5-12.
  2. Takano C, Seki M, Kim DW, Gardner H, McLaughlin RE, Kilgore PE, Kumasaka K, Hayakawa S. Development of a Novel Loop-Mediated Isothermal Amplification Method to Detect Guiana Extended-Spectrum (GES) β-Lactamase Genes in Pseudomonas aeruginosa. Front Microbiol. 2019 Feb 4;10:25.
  3. Hemelaar J, Elangovan R, Yun J, Dickson-Tetteh L, Fleminger I, Kirtley S, Williams B, Gouws-Williams E, Ghys PD; WHO–UNAIDS Network for HIV Isolation Characterisation.Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey, and trend analysis.Lancet Infect Dis. 2019 Feb;19(2):143-155.
  4. Hoque SA, Thongprachum A, Takanashi S, Mostafa SM, Saito H, Anwar KS, Nomura A, Hoque SA, Begum R, Sultana UN, Hossain T, Khamrin P, Okitsu S, Hayakawa S, Ushijima H. Alarming Situation of Spreading Enteric Viruses Through Sewage Water in Dhaka City: Molecular Epidemiological Evidences. Food Environ Virol. 2019 Mar;11(1):65-75.
  5. Kittigul L, Rupprom K, Che-Arsae M, Pombubpa K, Thongprachum A, Hayakawa S, Ushijima H. Occurrence of noroviruses in recycled water and sewage sludge: emergence of recombinant norovirus strains. J Appl Microbiol. 2019 Apr;126(4):1290-1301.
  6. Ishii W, Komine-Aizawa S, Takano C, Fujita Y, Morioka I, Hayakawa S. Relationship Between the Fecal Microbiota and Depression and Anxiety in Pediatric Patients With Orthostatic Intolerance. Prim Care Companion CNS Disord. 2019 Apr 11;21(2).
  7. Miki T, Takano C, Garcia IM, Grubbs BH. Construction and Evaluation of a Subcutaneous Splenic Injection Port for Serial Intraportal Vein Cell Delivery in Murine Disease Models.  Stem Cells Int. 2019 May 2;2019:5419501.
  8. Malasao R, Khamrin P, Kumthip K, Ushijima H, Maneekarn N. Molecular epidemiology and genetic diversity of human parechoviruses in children hospitalized with acute diarrhea in Thailand during 2011-2016. Arch Virol. 2019 Jul;164(7):1743-1752.
  9. Izaki S, Toyoshima S, Endo T, Kanegae K, Nunomura S, Kashiwakura JI, Sasaki-Sakamoto T, Nakamura R, Akiyama H, Ra C, Hayama K, Terui T, Okayama Y. Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs. Allergol Int. 2019 Jul;68(3):342-351.
  10. Acharya G, Bartolomei M, Carter AM, Chamley L, Cotton CF, Hasegawa J, Hasegawa Y, Hayakawa S, Kawaguchi M, Konwar C, Magawa S, Miura K, Nishi H, Salomon C, Sato K, Soejima H, Soma H, Sørensen A, Takahashi H, Tomita T, Whittington CM, Yuan V, O'Tierney-Ginn P. IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy.Placenta.2019 Sep1;84:4-8.
  11. Komine-Aizawa S, Jiang J, Mizuno S, Hayakawa S, Matsuo K, Boyd LF, Margulies DH, Honda M.MHC-restricted Ag85B-specific CD8+ T cells are enhanced by recombinant BCG prime and DNA boost immunization in mice.Eur J Immunol.2019 Sep;49(9):1399-1414.
  12. Pham NTK, Thongprachum A, Shimizu Y, Trinh QD, Okitsu S, Komine-Aizawa S, Shimizu H, Hayakawa S, Ushijima H.  Diversity of human parechovirus in infants and children with acute gastroenteritis in Japan during 2014-2016. Infect Genet Evol.2019 Aug 16;75:104001.
  13. Kumthip K, Khamrin P, Ushijima H, Maneekarn N. Enteric and non-enteric adenoviruses associated with acute gastroenteritis in pediatric patients in Thailand, 2011 to 2017. PLoS One. 2019 Aug1;14(8):e0220263.
  14. Hoque SA, Iizuka I, Kobayashi M, Takanashi S, Anwar KS, Islam MT, Hoque SA, Khamrin P, Okitsu S, Hayakawa S, Ushijima H.  Determining effectiveness of rotavirus vaccine by immunochromatography and reverse transcriptase polymerase chain reaction: A comparison. Vaccine.2019 Sep16;37(39):5886-5890.
  15. Okitsu S, Khamrin P, Takanashi S, Thongprachum A, Hoque SA, Takeuchi H, Khan MA, Hasan SMT, Iwata T, Shimizu H, Jimba M, Hayakawa S, Maneekarn N, Ushijima H. Molecular detection of enteric viruses in the stool samples of children without diarrhea in Bangladesh. Infect Genet Evol. 2019 Oct 17;77:104055.
  16. Takano C, Kuramochi Y, Seki M, Kim DW, Omagari D, Sasano M, Chang B, Ohnishi M, Kim EJ, Fuwa K, Kilgore PE, Hoshino T, Hayakawa S. Molecular serotype-specific identification of Streptococcus pneumoniae using loop-mediated isothermal amplification. Sci Rep. 2019 Dec 27;9(1):19823. 

2018

  1. Hoque SA, Kobayashi M, Takanashi S, Anwar KS, Watanabe T, Khamrin P, Okitsu S, Hayakawa S, Ushijima H. Role of rotavirus vaccination on an emerging G8P[8] rotavirus strain causing an outbreak in central Japan. Vaccine. 2018 Jan 2;36(1):43-49.
  2. Fuwa K, Seki M, Hirata Y, Yanagihara I, Nakura Y, Takano C, Kuroda K, Hayakawa S. Rapid and simple detection of Ureaplasma species from vaginal swab samples using a loop-mediated isothermal amplification method. Am J Reprod Immunol. 2018 Jan;79(1).
  3. Shibata T, Nerome K, Moriyama M, Hayakawa S, Kuroda K. Addition of an EGFP-tag to the N-terminal of influenza virus M1 protein impairs its ability to accumulate in ND10. J Virol Methods. 2018 Feb;252:75-79.
  4. Trinh QD, Pham NTK, Takada K, Komine-Aizawa S, Hayakawa S. Myelin Oligodendrocyte Glycoprotein-Independent Rubella Infection of Keratinocytes and Resistance of First-Trimester Trophoblast Cells to Rubella Virus In Vitro.Viruses. 2018 Jan 4;10(1).
  5. Takano C, Seki M, Shiihara H, Komine-Aizawa S, Kuroda K, Takahashi S, Ushijima H, Hayakawa S. Frequent isolation of extended-spectrum beta-lactamase-producing bacteria from fecal samples of individuals with severe motor and intellectual disabilities. J Infect Chemother. 2018 Mar;24(3):182-187.
  6. Seki M, Kilgore PE, Kim EJ, Ohnishi M, Hayakawa S, Kim DW. Loop-Mediated Isothermal Amplification Methods for Diagnosis of Bacterial Meningitis. Front Pediatr. 2018 Mar 12;6:57.
  7. Okitsu S, Hikita T, Thongprachum A, Khamrin P, Takanashi S, Hayakawa S, Maneekarn N, Ushijima H. Detection and molecular characterization of two rare G8P[14] and G3P[3] rotavirus strains collected from children with acute gastroenteritis in Japan. Infect Genet Evol. 2018 Apr 12;62:95-108.
  8. Seki M, Kim CK, Hayakawa S, Mitarai S. Recent advances in tuberculosis diagnostics in resource-limited settings.Eur J Clin Microbiol Infect Dis. 2018 Apr 19.[Epub ahead of print]
  9. Khamrin P, Kumthip K, Thongprachum A, Takanashi S, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H. Evaluation of Immunochromatographic Test for Dual Detection of Noroviruses and Group A Rotaviruses in Stool Samples. Clin Lab. 2018 May 1;64(5):793-796.
  10. Thongprachum A, Fujimoto T, Takanashi S, Saito H, Okitsu S, Shimizu H, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H. Detection of nineteen enteric viruses in raw sewage in Japan. Infect Genet Evol. 2018 May 16;63:17-23.
  11. Khandoker N, Thongprachum A, Takanashi S, Okitsu S, Nishimura S, Kikuta H, Yamamoto A, Sugita K, Baba T, Kobayashi M, Hayakawa S, Mizuguchi M, Ushijima H. Molecular epidemiology of rotavirus gastroenteritis in Japan during 2014-2015: Characterization of re-emerging G2P[4] after rotavirus vaccine introduction. J Med Virol. 2018 Jun;90(6):1040-1046.
  12. Pham NTK, Thongprachum A, Trinh QD, Okitsu S, Komine-Aizawa S, Shimizu H, Hayakawa S, Ushijima H.Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014-2016. Infect Genet Evol. 2018 Jul;61:16-19.
  13. Endo-Umeda K, Nakashima H, Komine-Aizawa S, Umeda N, Seki S, Makishima M. Liver X receptors regulate hepatic F4/80 + CD11b+ Kupffer cells/macrophages and innate immune responses in mice. Sci Rep. 2018 Jun 18;8(1):9281.
  14. Takada K, Komine-Aizawa S, Kuramochi T, Ito S, Trinh QD, Pham NTK, Sasano M, Hayakawa S. Lactobacillus crispatus accelerates re-epithelialization in vaginal epithelial cell line MS74. Am J Reprod Immunol. 2018 Sep;80(3):e13027.
  15. Majima-Horiuchi H, Komine-Aizawa S, Karasaki-Suzuki M, Izumi Y, Aizawa S, Hayakawa S. Synergistic induction of interferon-γ by interleukin-2, interleukin-12 and poly(I:C) in a human natural killer cell line. Immunol Med. 2018 Sep;41(3):136-141.
  16. Thongprachum A, Fujimoto T, Takanashi S, Saito H, Okitsu S, Shimizu H, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H. Detection of nineteen enteric viruses in raw sewage in Japan. Infect Genet Evol. 2018 Sep;63:17-23.
  17. Gotoda T, Takano C, Kusano C, Suzuki S, Ikehara H, Hayakawa S, Andoh A. Gut microbiome can be restored without adverse events after Helicobacter pylori eradication therapy in teenagers. Helicobacter. 2018 Dec;23(6):e12541.

2017

  1. Pham NT, Ushijima H, Thongprachum A, Trinh QD, Khamrin P, Arakawa C, Ishii W, Okitsu S, Komine-Aizawa S, Hayakawa S. Multiplex PCR for the Detection of 10 Viruses Causing Encephalitis/Encephalopathy and its Application to Clinical Samples Collected from Japanese Children with Suspected Viral. Clin Lab. 2017 Jan 1;63(1):91-100.
  2. Fuwa K, Hayakawa S. Mechanisms and possible controls of the in utero Zika virus infection: Where is the Holy Grail? Am J Reprod Immunol. 2017 Feb;77(2).
  3. Thongprachum A, Okitsu S, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H., Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016. Infect Genet Evol. 2017 Mar 20;51:86-88.
  4. Takada K, Komine-Aizawa S, Hirohata N, Trinh QD, Nishina A, Kimura H, Hayakawa S. Poly I:C induces collective migration of HaCaT keratinocytes via IL-8. BMC Immunol. 2017 Apr 24;18(1):19.
  5. Nishina A, Shimizu K, Koketsu M, Ninomiya M, Sato D, Suzuki T, Hayakawa S, Kimura H. 5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing IκBα-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages. Evid Based Complement Alternat Med. 2017;2017:7898973. doi: 10.1155/2017/7898973. Epub 2017 Apr 30.
  6. Nishina A, Itagaki M, Suzuki Y, Koketsu M, Ninomiya M, Sato D, Suzuki T, Hayakawa S, Kuroda M,Kimura H. Effects of Flavonoids and Triterpene Analogues from Leaves of Eleutherococcus sieboldianus (Makino) Koidz. 'Himeukogi' in 3T3-L1 Preadipocytes. Molecules. 2017 Apr 22;22(4).
  7. Thongprachum A, Khamrin P, Pham NT, Takanashi S, Okitsu S, Shimizu H, Maneekarn N, Hayakawa S, Ushijima H. Multiplex RT-PCR for rapid detection of viruses commonly causing diarrhea in pediatric patients. J Med Virol. 2017 May;89(5):818-824.
  8. Takanashi S, Thongprachum A, Okitsu S, Nishimura S, Kobayashi M, Kikuta H, Yamamoto A, Sugita K, Baba T, Hayakawa S, Mizuguchi M, Ushijima H. Molecular Epidemiological Traits of Group A Rotaviruses in Japanese Children During Transitional Period of Rotavirus Vaccine Implementation, 2011 - 2014. Clin Lab. 2017 May 1;63(5):961-970.
  9. Pham NTK, Thongprachum A, Baba T, Okitsu S, Trinh QD, Komine-Aizawa S, Shimizu H, Hayakawa S, Ushijima H. A 3-Month-Old Child with Acute Gastroenteritis with Enterovirus D68 Detected from Stool Specimen. Clin Lab. 2017 Jul 1;63(7):1269-1272.
  10. Takano C, Seki M, Kim DW, Kilgore PE, Fuwa K, Takahashi K, Inazaki T, Hayakawa S. Molecular Serotype-Specific Identification of Non-type b Haemophilus influenzae by Loop-Mediated Isothermal Amplification. Front Microbiol. 2017 Oct 4;8:1877.
  11. Khamrin P, Kumthip K, Supadej K, Thongprachum A, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Noroviruses and sapoviruses associated with acute gastroenteritis in pediatric patients in Thailand: increased detection of recombinant norovirus GII.P16/GII.13 strains. Arch Virol. 2017 Nov;162(11):3371-3380.
  12. Hirohata N, Komine-Aizawa S, Tamura M, Ochiai K, Sugitani M, Hayakawa S. Porphyromonas gingivalis Suppresses Trophoblast Invasion by Soluble Factors. J Periodontol. 2017 Dec;88(12):1366-1373.

2016

  1. Tran DN, Trinh QD, Pham NT, Pham TM, Ha MT, Nguyen TQ, Okitsu S, Shimizu H, Hayakawa S, Mizuguchi M, Ushijima H. Human rhinovirus infections in hospitalized children: clinical, epidemiological and virological features. Epidemiol Infect. 2016 Jan;144(2):346-54.
  2. Pham NT, Thongprachum A, Tran DN, Nishimura S, Shimizu-Onda Y, Trinh QD, Khamrin P, Ukarapol N, Kongsricharoern T, Komine-Aizawa S, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H. Antibiotic Resistance of Campylobacter jejuni and C. coli Isolated from Children with Diarrhea in Thailand and Japan. Jpn J Infect Dis. 2016 Jan 21;69(1):77-9.
  3. Okitsu S, Khamrin P, Hanaoka N, Thongprachum A, Takanashi S, Fujimoto T, Mizuguchi M, Shimizu H, Hayakawa S, Maneekarn N, Ushijima H. Cosavirus (family Picornaviridae) in pigs in Thailand and Japan. Arch Virol. 2016 Jan;161(1):159-63.
  4. Tran DN, Trinh QD, Pham NT, Vu MP, Ha MT, Nguyen TQ, Okitsu S, Hayakawa S, Mizuguchi M, Ushijima H. Clinical and epidemiological characteristics of acute respiratory virus infections in Vietnamese children. Epidemiol Infect. 2016 Feb;144(3):527-36.
  5. Khamrin P, Thongprachum A, Okitsu S, Hayakawa S, Maneekarn N, Ushijima H. Multiple astrovirus MLB1, MLB2, VA2 clades, and classic human astrovirus in children with acute gastroenteritis in Japan.  J Med Virol. 2016 Feb;88(2):356-60.
  6. Thongprachum A, Shimizu-Onda Y, Hayakawa S, Ushijima H. The virucidal effects against murine norovirus and feline calicivirus F4 as surrogates for human norovirus by the different additive concentrations of ethanol-based sanitizers.J Infect Chemother. 2016 Mar;22(3):191-3.
  7. Akasaka T, Shimizu-Onda Y, Hayakawa S, Ushijima H. The virucidal effects against murine norovirus and feline calicivirus F4 as surrogates for human norovirus by the different additive concentrations of ethanol-based sanitizers. J Infect Chemother. 2016 Mar;22(3):191-3.
  8. Thongprachum A, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H. Epidemiology of gastroenteritis viruses in Japan: Prevalence, seasonality, and outbreak. J Med Virol. 2016 Apr;88(4):551-70.
  9. Kudoh A, Miyakawa K, Matsunaga S, Matsushima Y, Kosugi I, Kimura H, Hayakawa S, Sawasaki T, Ryo A. H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. Front Microbiol. 2016 Jun 13;7:883.
  10.  Mikami Y, Fukushima A, Komiyama Y, Iwase T, Tsuda H, Higuchi Y, Hayakawa S, Kuyama K, Komiyama K.Cancer Lett. Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion. 2016 Aug 28;379(1):84-93.
  11. Khamrin P, Kumthip K, Yodmeeklin A, Supadej K, Ukarapol N, Thongprachum A, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Molecular characterization of norovirus GII.17 detected in healthy adult, intussusception patient, and acute gastroenteritis children in Thailand. Infect Genet Evol. 2016 Oct;44:330-3.
  12. Ishii W, Komine-Aizawa S, Hayakawa S. Antibiotics or Infection Itself? The Possible Importance of Inflammatory Cytokines on Mental States. J Clin Psychiatry. 2016 Dec;77(12):e1653.
  13. Ushijima H, Thongprachum A, Khamrin P, Takanashi S, Okitsu S, Maneekarn N, Hayakawa S. Evaluation of Immunochromatography Tests and New Enzyme Immunoassay for Detection of Novel GII.17 Norovirus in Stool Samples. Jpn J Infect Dis. 2016 Dec 22.
  14. Trinh QD, Pham NT, Fuwa K, Takada K, Komine-Aizawa S, Honda M, Ushijima H, Hayakawa S. High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells.Clin Lab. 2016 Dec 1;62(12):2305-2311.
  15. Ushijima H, Machida S, Nomura A, Khamrin P, Tran DN, Nomura H, Hayakawa S. Immune responses against norovirus GII.4 virus-like particles in mice. Acta Virol. 2016;60(4):339-346.

2015

  1. Komine-Aizawa S, Hirohata N, Aizawa S, Abiko Y, Hayakawa S. Porphyromonas gingivalis lipopolysaccharide inhibits trophoblast invasion in the presence of nicotine. Placenta. 2015 Jan;36(1):27-33.
  2. Komine-Aizawa S, Masuda H, Mazaki T, Shiono M, Hayakawa S, Takayama T. Plasma osteopontin predicts inflammatory bowel disease activities. Int Surg. 2015 Jan;100(1):38-43.
  3. Pham NT, Trinh QD, Khamrin P, Ukarapol N, Kongsricharoern T, Yamazaki W, Komine-Aizawa S, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H. Loop-Mediated Isothermal Amplification (LAMP) for Detection of Campylobacter jejuni and C. coli in Thai Children with Diarrhea. Jpn J Infect Dis. 2015;68(5):432-3.
  4. Chuchaona W, Khamrin P, Yodmeeklin A, Saikruang W, Kongsricharoern T, Ukarapol N, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Detection and characterization of a novel human parechovirus genotype in Thailand. Infect Genet Evol. 2015 Apr;31:300-4.
  5. Ushijima H, Thongprachum A, Tran DN, Fujimoto T, Hanaoka N, Okitsu S, Takanashi S, Mizuguchi M, Hayakawa S.　 Rapid diagnostic tests apply for pediatric infections at outpatient clinic setting. Clin Lab. 2015;61(1-2):195-9.
  6. Thongprachum A, Takanashi S, Kalesaran AF, Okitsu S, Mizuguchi M, Hayakawa S, Ushijima H. Four-year study of viruses that cause diarrhea in Japanese pediatric outpatients. J Med Virol. 2015 Jul;87(7):1141-8.
  7. Tran DN, Pham TM, Ha MT, Hayakawa S, Mizuguchi M, Ushijima H. Molecular epidemiology of influenza A virus infection among hospitalized children in vietnam during post-pandemic period. J Med Virol. 2015 Jun;87(6):904-12.
  8. Pham NT, Ushijima H, Trinh QD, Khamrin P, Komine-Aizawa S, Okitsu S, Maneekarn N, Hayakawa S. Prevalence and Antimicrobial Resistance of Campylobacterjejuni and Campylobacter coli from Adult Hospitalized Patients with Diarrhea in Thailand. Clin Lab. 2015;61(11):1809-12.
  9. Khamrin P, Thongprachum A, Takanashi S, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H. Evaluation of immunochromatography tests for detection of novel GII.17 norovirus in stool samples. Euro Surveill. 2015 Jul 16;20(28). Erratum in: Euro Surveill. 2015;20(29):21191.
  10. Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T. Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the FC receptor γ-chain. J Allergy Clin Immunol. 2015 Dec 15.
  11. Osaka S, Hayakawa S. Surgery for Peripheral Nerve Sheath Tumors during the “Early Meiji Period” in 19th Century Japan. 日大医誌74(6):292-294 (2015)

2014

  1. Manzoor R, Kuroda K, Yoshida R, Tsuda Y, Fujikura D, Miyamoto H, Kajihara M, Kida H, Takada A. Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity. J Biol Chem. 2014 Jan 28. Mar 14;289(11):7599-614.
  2. Thongprachum A, Chan-It W, Khamrin P, Saparpakorn P, Okitsu S, Takanashi S, Mizuguchi M, Hayakawa S, Maneekarn N, Ushijima H. Molecular epidemiology of norovirus associated with gastroenteritis and emergence of norovirus GII.4 variant 2012 in Japanese pediatric patients. Infect Genet Evol. 2014 Feb 4;23C:65-73. doi: 10.1016/j.meegid.2014.01.030. Apr;23:65-73.
  3. Osaka S, Osaka E, Kojima T, Yoshida Y, Tokuhashi Y. Long-term Outcome Following Surgical Treatment of Sacral Chordoma. J Surg Oncol. 2014 Mar;109(3):184-8. doi: 10.1002/jso.23490. Epub 2013 Nov 19.
  4. Tran DN, Nguyen TQ, Nguyen TA, Hayakawa S, Mizuguchi M, Ushijima H. Human bocavirus in children with acute respiratory infections in Vietnam. J Med Virol. 2014 Jun;86(6):988-94.
  5. Okitsu S, Khamrin P, Thongprachum A, Kalesaran AF, Takanashi S, Shimizu H, Maneekarn N, Mizuguchi M, Hayakawa S, Ushijima H. Molecular characterization and sequence analysis of the 2B region of Aichivirus C strains in Japan and Thailand. Infect Genet Evol. 2014 Aug;26:89-94.
  6. Suzaki A, Komine-Aizawa S, Hayakawa S. Suppression of osteoblast Toll-like receptor 2 signaling by endothelin-1. J Orthop Res. 2014 Jul;32(7):910-4.
  7. Okitsu S, Khamrin P, Thongprachum A, Nishimura S, Kalesaran AF, Takanashi S, Shimizu H, Hayakawa S, Mizuguchi M, Ushijima H. Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan. Infect Genet Evol. 2014 Dec;28:125-9.
  8. Ushijima H, Nishimura S, Thongprachum A, Shimizu-Onda Y, Tran DN, Pham NT, Takanashi S, Dey SK, Okitsu S, Yamazaki W, Mizuguchi M, Hayakawa S.  Sensitive and rapid detection of campylobacter species from stools of children with diarrhea in Japan by the loop-mediated isothermal amplification method. Jpn J Infect Dis. 2014;67(5):374-8.
  9. Khamrin P, Thongprachum A, Okitsu S, Maneekarn N, Hayakawa S, Ushijima H. Comparison of three rapid tests for detection of norovirus in stool samples of acute gastroenteritis pediatric patients. J Trop Pediatr. 2014 Dec;60(6):481-3.
  10. Saikruang W, Khamrin P, Suantai B, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Detection of diarrheal viruses circulating in adult patients in Thailand. Arch Virol. 2014 Dec;159(12):3371-5.

2013

  1. Khamrin P, Thongprachum A, Kikuta H, Yamamoto A, Nishimura S, Sugita K, Baba T, Kobayashi M, Okitsu S, Hayakawa S, Shimizu H, Maneekarn N, Ushijima H. Three clusters of Saffold viruses circulating in children with diarrhea in Japan. Infect Genet Evol. 2013 Jan;13:339-43
  2. Tran DN, Pham TM, Ha MT, Tran TT, Dang TK, Yoshida LM, Okitsu S, Hayakawa S, Mizuguchi M, Ushijima H. Molecular epidemiology and disease severity of human respiratory syncytial virus in Vietnam. PLoS One. 2013;8(1):e45436
  3. Thongprachum A, Chan-It W, Khamrin P, Okitsu S, Nishimura S, Kikuta H, Yamamoto A, Sugita K, Baba T, Mizuguchi M, Maneekarn N, Hayakawa S, Ushijima H.　Reemergence of new variant G3 rotavirus in Japanese pediatric patients, 2009-2011. Infect Genet Evol. 2013 Jan;13:168-74.
  4. Sawai-Kuroda R, Kikuchi S, Shimizu YK, Sasaki Y, Kuroda K, Tanaka T, Yamamoto T, Sakurai K, Shimizu K. A polyphenol-rich extract from Chaenomeles sinensis (Chinese quince) inhibits influenza A virus infection by preventing primary transcription in vitro. J Ethnopharmacol. 2013 Apr 19;146(3):866-72.
  5. Tanaka T, Kuroda K, Ikeda M, Wakita T, Kato N, Makishima M. Hepatitis C virus. NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices. J Lipid Res. 2013 Apr;54(4):881-92.
  6. Trinh QD, Pham NT, Le Nguyen NT, Lam BQ, Le Phan KT, Truong KH, Le TQ, Nguyen HT, Tang TC, Izumi Y, Komine-Aizawa S, Ushijima H, Hayakawa S. Seroprevalence of Chlamydophila pneumoniae in HIV-infected children in Vietnam. J Infect Chemother. 2013 Jun;19(3):538-41.
  7. Shimizu-Onda Y, Akasaka T, Yagyu F, Komine-Aizawa S, Tohya Y, Hayakawa S, Ushijima H. The virucidal effect against murine norovirus and feline calicivirus as surrogates for human norovirus by ethanol-based sanitizers. J Infect Chemother. 2013 Aug;19(4):779-81.
  8. Okitsu S, Khamrin P, Thongprachum A, Kongkaew A, Maneekarn N, Mizuguchi M, Hayakawa S, Ushijima H. Whole-genomic analysis of G3P[23], G9P[23] and G3P[13] rotavirus strains isolated from piglets with diarrhea in Thailand, 2006-2008. Infect Genet Evol. 2013 Aug;18:74-86.
  9. Thongprachum A, Khamrin P, Chan-It W, Malasao R, Chaimongkol N, Okitsu S, Mizuguchi M, Maneekarn N, Hayakawa S, Ushijima H. Emergence of norovirus GII/4 2006a and 2006b variants in hospitalized children with acute gastroenteritis in Thailand. Clin Lab. 2013;59(3-4):271-6.
  10. Tran DN, Nguyen TQ, Nguyen TA, Hayakawa S, Mizuguchi M, Ushijima H. Human bocavirus in children with acute respiratory infections in Vietnam. J Med Virol. 2013 Oct 12.
  11. Tanaka T, Kuroda K, Ikeda M, Kato N, Shimizu K, Makishima M. Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging. J Biosci Bioeng. 2013 Nov;116(5):620-3. 

2012

  1. Okitsu S, Khamrin P, Thongprachum A, Hidaka S, Kongkaew S, Kongkaew A, Maneekarn N, Mizuguchi M, Hayakawa S, Ushijima H.Sequence analysis of porcine kobuvirus VP1 region detected in pigs in Japan and Thailand. Virus Genes. 2012 Apr;44(2):253-7.
  2. Khamrin P, Thongprachum A, Shimizu H, Okitsu S, Mizuguchi M, Hayakawa S, Maneekarn N, Ushijima H Detection of human bocavirus 1 and 2 from children with acute gastroenteritis in Japan. J Med Virol. 2012 Jun;84(6):901-5
  3. Tran DN, Pham NT, Tran TT, Khamrin P, Thongprachum A, Komase K, Hayakawa S, Mizuguchi M, Ushijima H. Phylogenetic analysis of rubella viruses in Vietnam during 2009-2010. J Med Virol. 2012 Apr;84(4):705-10
  4. Khamrin P, Malasao R, Chaimongkol N, Ukarapol N, Kongsricharoern T, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Circulating of human bocavirus 1, 2, 3, and 4 in pediatric patients with acute gastroenteritis in Thailand. Infect Genet Evol. 2012 Apr;12(3):565-9.
  5. Trinh QD, Pham NT, Le Nguyen NT, Lam BQ, Le Phan KT, Truong KH, Izumi Y, Komine-Aizawa S, Mizuguchi M, Ushijima H, Hayakawa S. Drug Resistance Mutations in the HIV Type 1 Protease and Reverse Transcriptase Genes in Antiretroviral-Naive Vietnamese Children.
    AIDS Res Hum Retroviruses. 2012 Mar 6. [Epub ahead of print]
  6. Komine-Aizawa S, Suzaki A, Trinh QD, Izumi Y, Shibata T, Kuroda K, Hayakawa S. H1N109　influenza　A virus infection of  immortalized first trimester human trophoblast cell lines.　Am J Reprod Immunol. 2012 Sep;68(3):226-32
  7. Nishikawa T, Shimizu K, Tanaka T, Kuroda K, Takayama T, Yamamoto T, Hanada N, Hamada Y. Bacterial neuraminidase rescues influenza virus replication from inhibition by a neuraminidase inhibitor. PLoS One. 2012;7(9):e45371. doi: 10.1371/journal.pone.0045371. Epub 2012 Sep 18.
  8. Trinh QD, Pham NT, Le Nguyen NT, Lam BQ, Le Phan KT, Truong KH, Le TQ, Nguyen HT, Tang TC, Izumi Y, Komine-Aizawa S, Ushijima H, Hayakawa S. Seroprevalence of Chlamydophila pneumoniae in HIV-infected children in Vietnam. Infect Chemother. 2012 Oct 2.
  9. Dey SK, Nishimura S, Okitsu S, Hayakawa S, Mizuguchi M, Ushijima H. Comparison of immunochromatography, PCR and culture methods for the detection of Campylobacter bacteria. Microbiol Methods. 2012 Dec;91(3):566-8.
  10. Dey SK, Hoq I, Okitsu S, Hayakawa S, Ushijima H.　Prevalence, seasonality, and peak age of infection of enteric adenoviruses in Japan, 1995-2009. Epidemiol Infect. 2012 Jul 20:1-3.

2011

  1. Negishi M, Izumi Y, Aleemuzzaman S, Inaba N, Hayakawa S.Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma production by decidual mononuclear cells (DMNC) is interleukin (IL)-2 and IL-12 dependent. Am J Reprod Immunol. 2011 Jan;65(1):20-7.
  2. Uenogawa K, Hatta Y, Arima N, Hayakawa S, Sawada U, Aizawa S, Yamamoto T, Takeuchi J. Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma. Int J Mol Med. 2011 Nov;28(5):835-9.
  3. Suzaki A, Hayashi K, Kosuge K, Soma M, Hayakawa S.Disseminated gonococcal infection in Japan: a case report and literature review. Intern Med. 2011;50(18):2039-43
  4. Komine-Aizawa S, Izumi Y, Imai S, Fujita K, Hayakawa S.The therapeutic potential of the recombinant antigen from Dirofilaria immitis (rDiAg) for immune-mediated pregnancy loss. J Reprod Immunol. 2011 Dec;92(1-2):21-6

2010

  1. Trinh QD, Pham NT, Lam BQ, Le TP, Truong KH, Le TQ, Vo HT, Tang TC, Ha TM, Izumi Y, Mizuguchi M, Hayakawa S, Ushijima H  Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004-2005. J Trop Pediatr. 2009 Dec;55(6):399-401.
  2. Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S. Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis. Clin Vaccine Immunol. 2010 Oct;17(10):1500-6
  3. Shinojima Y, Terui T, Hara H, Kimura M, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, Nagase H.Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation. J Dermatol Sci. 2010 Aug;59(2):98-106.

2009

  1. Shibata T, Tanaka T, Shimizu K, Hayakawa S, Kuroda K Immunofluorescence imaging of the influenza virus M1 protein is dependent on the fixation method.      J Virol Methods. 2009 Mar;156(1-2):162-5.
  2. Hitoshi Ohto H, Yonemura Y, Takeda J, Inada E, Hanada R, Hayakawa S, Miyano T,Kai K, washi W,Muto K, Asai F. Guidelines for Managing Conscientious Objection to Blood Transfusion Transfusion  Medicine Reviews 2009 Jul;23(3):221-8.
  3. Chen SS, Chen WC, Hayakawa S, Li PC, Chien CT. Acute urinary bladder distension triggers ICAM-1-mediated renal oxidative injury via the norepinephrine -renin-angiotensin II system in rats. J Formos Med Assoc. 2009 Aug;108(8):627-35.
  4. Trinh QD, Izumi Y, Komine-Aizawa S, Shibata T, Shimotai Y, Kuroda K, Mizuguchi M, Ushijima H, Mor G, Hayakawa S.  H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis. Am J Reprod Immunol. 2009 Sep;62(3):139-46.
  5. Yen YH, Chen WC, Hayakawa S, Chien CT. In-chern-hau-tang and genipin reduces acute urinary bladder distension evoked sympathetic activation-induced hepatic dysfunction in rats. Am J Chin Med. 2009;37(2):339-49.

2008

  1. Komine-Aizawa S, Majima H, Yoshida-Noro C, Hayakawa S. Stimuli through Toll-like receptor (TLR) 3 and 9 affect human chorionic gonadotropin (hCG) production in a choriocarcinoma cell line. J Obstet Gynaecol Res. 2008 Apr;34(2):144-51.
  2. Naganawa S, Yokoyama M, Shiino T, Suzuki T, Ishigatsubo Y, Ueda A, Shirai A, Takeno M, Hayakawa S, Sato S, Tochikubo O, Kiyoura S, Sawada K, Ikegami T, Kanda T, Kitamura K, Sato H..Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity.　 PLoS ONE. 12;3(9)　e3206 1-9 　2008

2007

  1. Hayakawa S,Komine-AizawaS,Osaka S,Iida T,Hayakawa J,Nishinarita S,Nemoto N: Rembrandt’s Maria Bockenolle has a butterfly rash and digital deformities: Overlapping syndrome of rheumatoid arthritis and systemic lupus erythematosus. Med Hypotheses. 68:906-9. 2007
  2. Watanabe N, Hatano J, Asahina K,Hayakawa S:Molecular cloning and histlogical localization of a LH like substance in bottlenose dolphin (Tursiops truncatus) placenta. Comp Biochem Physiol A Mol Integr Physiol. 146(1):105-18　2007
  3. Murayama R, Harada Y, Shibata T, Kuroda K, Hayakawa S, Shimizu K, Tanaka T. Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection. Biochem Biophys Res Commun. 362(4):880-5. 2007
  4. Chishima F, Hayakawa S, Yamamoto T, Sugitani M, Karasaki-Suzuki M, Sugita K, Nemoto N.　Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. Am J Reprod Immunol. 　57:218-26. 2007

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